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Balbharti Maharashtra State Board 11th Biology Important Questions 16 Skeleton and Movement Important Questions and Answers.

Maharashtra State Board 11th Biology Important Questions Chapter 16 Skeleton and Movement

Question 1.
Name the three types of muscles which bring about movements in humans.
Answer:

1. Smooth / non-striated / visceral / involuntary muscles
2. Cardiac muscles
3. Skeletal / straited / voluntary muscles.

Question 2.
Name the type of muscles which bring about running and speaking.
Answer:
Skeletal muscles (Voluntary muscles)

Question 3.
Name the muscles which do not contract as per our will.
Answer:
Involuntary muscles (smooth muscles and cardiac muscles)

Question 4.
Which type of muscles show rhythmic contractions?
Answer:
Cardiac muscles

Question 5.
Which type of muscle is present in the diaphragm of the respiratory system?
Answer:
Skeletal muscle

Question 6.
State the functions of:

1. Smooth muscles
2. Cardiac muscles
3. Striated muscles

Answer:

1. Smooth muscles: They bring about involuntary movements like peristalsis in the alimentary canal, constriction and dilation of blood vessels.
2. Cardiac muscles: They bring about contraction and relaxation of the heart.
3. Striated muscles: They control voluntary movements of limbs, head, trunk, eyes, etc.

Question 7.
What is locomotion?
Answer:
The change in locus of whole body of living organism from one place to another place is called locomotion.

Question 8.
State the four basic types of locomotory movements seen in animals.
Answer:
The four basic types locomotory movements seen in animals are:

1. Amoeboid movement: It is performed by pseudopodia, e.g. leucocytes.
2. Ciliary movement: It is performed by cilia, e.g. ciliated epithelium. In Paramoecium, cilia help in passage of food through cytopharynx.
3. Whirling movement: It is performed by flagella, e.g. sperms.
4. Muscular movement: It is performed by muscles, with the help of bones and joints.

Question 9.
All locomotions are movements but all movements are not locomotion. Justify
Answer:
Locomotion occurs when body changes its position, however all movements may not result in locomotion. Thus, all locomotions are movements but all movements are not locomotion.

Question 10.
Kriti was diagnosed with knee tendon injury. She asked the doctor whether she will be able to walk due to the injury? If not then state the reason.
Answer:
Knee tendon injury affects the ability to walk. Kriti may not be able to walk freely as the tendons attached to the bones help in the movement of the parts of skeleton.

Question 11.
Explain the types of straited muscles.
Answer:
On the basis of movements striated muscles are of three types:

1. Agonists: These are considered as the prime movers. They bring about the initial movement of a part.
   e.g. biceps
2. Antagonists: They bring about the action opposite to that of prime movers. e.g. Triceps.
3. Svnergists They assist the prime movers. e.g. Brachialis assist biceps.

Question 12.
Describe the antagonistic muscles in detail.
Answer:
Following are the important antagonistic muscles:

1. Flexor and extensor: Flexor muscle on contraction results into bending or flexion of joint. e.g. Biceps. Extensor muscle on contraction results in straightening or extension of a joint. e.g. Triceps.
2. Abductor and adductor: Abductor muscle moves a body part away from the body axis. e.g. Deltoid muscle of shoulder moves the arm away from the body. Adductor muscle moves a body part towards the body axis.
   e.g. L.atissirnus dorsi of shoulder moves the arm near the body.
3. Pronator and supinator: Pronator turns the palm downwards and supinator turns the palm upward.
4. Levator and depressor: Levator raises a body part and the depressors lower the body part.
5. Protractor and retractor: Protractor moves forward, whereas the retractor moves backward.
6. Sphincters: Circular muscles present in the inner walls of anus, stomach. etc., for closure and opening.

Question 13.
Describe the structure of myosin and actin filaments, with the help of neat and labelled diagram.
Answer:
i. Myosin filament:

1. Each myosin filament is a polymerized protein. Many meromyosins (monomeric proteins) constitute one thick filament.
2. Myosin molecule consists of two heavy chains (heavy meromyosin / HMM) coiled around each other forming a double helix. One end of each of these chains is projected outwardly is known as cross bridge. This end folds to form a globular protein mass called myosin head.
3. Two light chains are associated with each head forming 4 light chains/light meromyosin / LMM.
4. Myosin head has a special ATPase activity. It can split ATP to produce energy.
5. Myosin contributes 55% of muscle proteins.
6. In sarcomere, myosin tails are arranged to point towards the centre of the sarcomere and the heads point to the sides of the myofilament band.
   

ii. Actin filament: It is a complex type of contractile protein. It is made up of three components:

1. F actin: It forms the backbone of actin filament. F actin is made up of two helical strands. Each strand is composed of polymerized G actin molecules. One ADP molecule is attached to G actin molecule.
2. Tropomyosin: The actin filament contains two additional protein strands that are polymers of tropomyosin molecules. Each strand is loosely attached to an F actin. In the resting stage, tropomyosin physically covers the active myosin-binding site of the actin strand.
3. Troponin: It is a complex of three globular proteins, is attached approx. 2/3^rd distance along each tropomyosin molecule. It has affinity for actin, tropomyosin and calcium ions. The troponin complex is believed to attach the tropomyosin to the actin. The strong affinity of troponin for calcium ions is believed to initiate the contraction process.
   

Question 14.
A muscle can only pull and not push the bone. Why?
Answer:
The fundamental characteristic of the muscle is contraction. Therefore, muscle can only pull and not push the bone.

Question 15.
Explain the physiology of muscle contraction.
Answer:
When the muscles are relaxed, the active sites remain covered with tropomyosin and troponin complex. Due to this, myosin cannot interact with active site of actin and thus contraction cannot occur.

1. When an impulse (action potential) comes to muscle through motor end plate, it spreads throughout the sarcolemma of the myofibril.
2. The transverse tubules of sarcoplasmic reticulum release large number of Ca⁺⁺ ions into sarcoplasm. These calcium ions interact with the troponin molecules and the interaction inactivates troponin-tropomyosin complex. This causes change in the structure of tropomyosin.
3. As a result, tropomyosin gets detached from the active site of actin (F actin) filament, exposing the active site for actin.
4. The myosin head cleaves the ATP to derive energy and gets attached to the uncovered active site of actin. This results into the formation of acto-myosin complex.
5. The myosin heads are now tilted backwards and pull the attached actin filament inwardly. This results in contraction of the muscle fibres.

Question 16.
Why do we shiver during winter?
Answer:

1. Humans are homeotherms as they can regulate their body temperature with respect to the surrounding temperature. During winter, when temperature falls, the thermoreceptors detect the change in temperature and send signals to the brain.
2. Shivering reflex i.e. rapid contraction of muscles is triggered by the brain to generate heat and raise the body temperature.

Question 17.
Write a short note on role of calcium ions in contraction and relaxation of muscles.
Answer:
Calcium ions play a major role in contraction and relaxation of muscles.

1. Calcium ions are released from the sarcoplasm during muscle contraction and stored in sarcoplasmic reticulum during muscle relaxation.
2. When a skeletal muscle is excited and an action potential travels along the T tubule, the concentration of calcium ions increases.
3. These calcium ions bind to troponin which in turn undergoes a conformational change that causes tropomyosin to move away from the myosin-binding sites on actin. Once these binding sites are free, myosin heads bind to them to form cross-bridges and the muscle fiber contracts.
4. The decrease in calcium ion concentration in the sarcoplasmic reticulum causes tropomyosin to slide back and block the myosin binding sites on actin. This causes the muscle to relax.

[Note: Students can scan the adjacent Q.R code to get conceptual clarity with the aid of a relevant video.]

Question 18.
Muscle contraction and relaxation are active processes. Give reason.
Answer:
Muscle contraction and relaxation are active processes as during both the processes energy is utilized by hydrolysis of ATP into ADP and inorganic phosphate by the enzyme ATPase.

Question 19.
Describe the properties of muscles observed on electrical stimulation.
Answer:
Properties of muscles observed on electrical excitation:

1. Single muscle twitch: It is a muscle contraction initiated by a single brief-stimulation. It occurs in 3 stages: a latent period of no contraction, a contraction period and a relaxation period.
2. Summation: If the muscle is stimulated before the end of the twitch, it generates greater tension i.e., summation or addition of effect takes place. Repeated stimuli will produce increasing strength of contraction (stair case phenomenon).
3. Tetanus: If stimulation is very rapid and frequent the muscle does not have time to relax. It remains in a
   state of contraction called tetanus.
4. Rcfraètory period: Immediately aller one stimulus, the muscle fibre cannot respond to another stimulus. This resting or refractory period is about 0.02 seconds.
5. Threshold stimulus: For a muscle fibre to contract, a certain minimum strength or intensity of stimulus is required. This is called threshold stimulus.
6. All or none principie: A stimulus below threshold will not result in contraction. A threshold stimulus will result in contraction. This contraction leads to maximum force. Higher stimulus will not increase force of contraction i.e. a muscle libre contracts either ftilly or not at all. This is ‘all or none’ principle. All types of muscle and nerve fibres obey this law.
7. Oxygen debt: During strenuous exercise, the oxygen supply of muscle rapidly becomes insufficient to maintain oxidative phosphorylation of respiratory substrate. At this stage, muscles contract anaerobically and accumulate lactic acid produced by anaerobic glycolysis. Lactic acid produces less AlP and is toxic. It causes tiredness, pain and muscle cramps. During recovery, oxygen consumption of the muscle far exceeds than that in the resting state. This extra oxygen consumed during recovery is called oxygen debt of the muscle.

Note: The duration of refractory period varies with the muscle involved. Cardiac muscles have a longer refractory period of about 250 msec whereas skeletal muscles have a short refractory period of about I msec]

Question 20.
What is difference between endoskeleton and exoskeleton?
Answer:
The supportive structures present inside the body form the endoskeleton and when the supportive structures are present on the outer surface of the body they form exoskeleton.

Question 21.
Name the tissues that form the structural framework of the body.
Answer:
Cartilage and bone

Question 22.
What type of bones are present in our body?
Answer:
Long bones, short bones, flat bones, irregular bones and sesamoid bones.

Question 23.
How do bones help in various ways?
Answer:

1. Bones form the framework of our body and thus provide shape to the body.
2. They protect vital organs thus help in the smooth functioning of body.
3. The joints between the bones help in movement and locomotion.
4. They provide firm surface for attachment of muscles.
5. They are reservoirs of calcium and form important site for hemopoiesis.

Question 24.
Explain the three types of lever found in human body.
Answer:
The three types of lever are as follows:

1. Class I lever: The joint between the first vertebra and occipital condyle of skull is an example of Class I lever. The force is directed towards the joints (fulcrum); contraction of back muscle provides force while the part of head that is raised acts as resistance.
   
2. Class II lever: Human body raised on toes is an example of Class II lever. Toe acts as fulcrum, contracting calf muscles provide the force while raised body acts as resistance.
   
3. Class III lever: Flexion of forearm at elbow exhibit lever of class III. Elbow joint acts as fulcrum and radius, ulna provides resistance. Contracting bicep muscles provides force for the movement.
   

Question 25.
Give an account of bones of human skull.
Answer:
Skull is made up of 22 bones. It is located at the superior end of vertebral column. The bones of skull are
joined by fixed or immovable joints except for jaw.
Skull consists of cranium or brain box and facial bones.

i. Cranium: It is made up of four median bones and two paired bones.

1. Frontal bone: It is median bone (unpaired) forming forehead, roof of orbit (eye socket) and the most anterior part of cranium. It is connected to two parietals, sphenoid and ethmoid bone.
2. Parietal bones: These paired bones form the roof of cranium and greater portion of sides of the cranium.
3. Temporal bones: These paired bones are situated laterally just above the ear on either side. Each temporal bone gives out zygomatic process that joins zygomatic bone to form zygomatic arch. Just at the base of zygomatic process is mandibular fossa, a depression for mandibles (lower jaw bone) that forms the only movable joint of the skull. This bone harbors the ear canal that directs sound waves into the ear. The processes of temporal bones provide points for attachment for various muscles of neck and tongue.
4. Occipital bone: It is a single bone present at the back of the head. It forms the posterior part and most of the base of cranium. The inferior part of this bone shows foramen magnum, the opening through which medulla oblongata connects with spinal cord. On the either sides of foramen magnum are two prominent protuberances called occipital condyles. These fit into the corresponding depressions present in 1st vertebra.
5. Sphenoid bone: Median bone present at the base of the skull that articulates with all other cranial bones and holds them together. This butterfly shaped bone has a saddle shaped region called sella turcica. In this hypophyseal fossa, the pituitary gland is lodged.
6. Ethmoid bone: This median bone is spongy in appearance. It is located anterior to sphenoid and posterior to nasal bones. It contributes to formation of nasal septum and is major supporting structure of nasal cavity.

ii. Facial Bones: Fourteen facial bones give a characteristic shape to the face. The growth of face stops of the age of 16.
Following bones comprise the facial bones:

1. Nasals: These are paired bones that form the bridge of nose.
2. Maxillae: These form the upper jaw bones. They are paired bones that join with all facial bones except mandible. Upper row of teeth are lodged maxillae.
3. Palatines: These are paired bones forming the roof of buccal cavity or floor of the nasal cavity.
4. Zygomatic bones: They are commonly called as cheek bones.
5. Lacrimal bones: These are the smallest amongst the facial bones.
   These bones form the medial wall of each orbit. They have lacrimal fossa that houses lacrimal sacs. These sacs gather tears and send them to nasal cavity.
6. Inferior nasal conchae: They form the part of lateral wall of nasal cavity. They help to swirl and filter air before it passes to lungs.
7. Vomer: The median, roughly triangular bone that forms the inferior portion of nasal septum.
8. Mandible: This median bone forms the lower jaw. It is the largest and strongest facial bone. It is the only movable bone of skull. It has curved horizontal body and two perpendicular branches i.e. rami. These help in attachment of muscles. It has lower row of teeth lodged in it.

Question 26.
Give an account of hyoid bone.
Answer:

1. It is a ‘U’ shaped bone that does not articulate with any other bone.
2. It is suspended from temporal bone by ligaments and muscles.
3. It is located between mandible and larynx.
4. It has horizontal body and paired projections called horns.
5. It provides site for attachment of some tongue muscles and muscles of neck and pharynx.
   

Question 27.
Sketch and label the anterior and ‘entraI view of skull.
Answer:

Question 28.
Mention the sutures in skull along with their location.
Answer:
Skull has many sutures (type of immovable joints) present, out of which four prominent ones are:

1. Coronal suture; Joins frontal bone with parietals.
2. Sagittal suture: Joins two parietal bones.
3. Lambdiodal suture: Joins two parietal bones with occipital bone.
4. Lateral/squamous sutures: Joins parietal and temporal bones on lateral side.

Question 29.
What are ear ossicles?
Answer:
The three tiny bones present in each middle ear namely malleus, incus and stapes, together are called ‘ear ossicles’

Question 30.
Draw a neat and labelled diagram of ear ossicles.
Answer:

Question 31.
Write a note on human vertebral column. Sketch and label the structure of the vertebral column.
Answer:

1. Human vertebral column or backbone is a part of axial skeleton.
2. It is made up of a chain of irregular bones called vertebrae.
   
3. Humans have 33 vertebrae in early years of growth, whereas adults have 26 vertebrae.
4. In adults, five sacral vertebrae lìjse to tòrm one sacrum and four coccygeal vertebrae fuse to form single coccyx.

Question 32.
Explain the cervical vertebrae in detail.
Answer:

1. Atlas vertebrae:
   
2. It is the 1^st cervical vertebra.
3. It is a ring like bone and consists of anterior and posterior arches.
4. It does not have centrum and spinous process.
5. The transverse processes and transverse foramina of atlas are large.
6. The vertebral foramen is large and divided into two parts by transverse ligament.
7. Spinal cord passes through anterior compartment.
8. Anterior zygopophyses are replaced by facets for attachment with occipital condyle of skull that forms ‘Yes joint’.

ii. Axis vertebrae:

1. It is the 2^nd cervical vertebrae.
2. The centrum of this vertebra gives out tooth-like odontoid process.
   
3. Odontoid process fits into the anterior portion of vertebral foramen of atlas vertebra thereby forming pivot joint, also known as ‘No joint’.

iii. Typical cervical vertebrae:

1. Vertebrae number 3 to 6 are called as typical cervical vertebrae.
2. They show short centrum and bifid spinous process.
3. The transverse processes of these vertebrae are reduced; each having large vertebrarterial canal at its base for the passage of vertebral artery.

iv. 7^th cervical vertebra (Vertebra prominens): It is the largest cervical vertebra where the neural spine is straight.

Question 33.
Write a note on thoracic vertebrae. Sketch and label thoracic vertebrae.
Answer:

1. There are 12 thoracic vertebrae found in the chest region.
2. The centrurn of thoracic vertebrae is heart shaped and all the processes are well developed.
3. Except for 11^th and 12^th vertebrae; transverse process of other thoracic vertebrae show facets for attachment with ribs.
   

Question 34.
Elaborate on lumbar vertebrae with help of a neat and labelled diagram.
Answer:

1. There are 5 lumbar vertebrae.
2. They are well developed vertebrae and exhibit all the characters of a typical vertebrae.
3. The centrum of the lumbar vertebrae is kidney shaped.

Question 35.
Give an account on:
i. Sacrum
ii. Coccyx
Answer:
i. Sacrum:

1. It is a triangular bone formed by the fusion of five sacral vertebrae.
2. It is located in pelvic cavity between two hip bones.
3. The anterior end of sacrum is broad and posterior end is narrow.
4. It consists of vertebral foramina formed by the fusion of vertebrae.
5. The reduced neural spines can be observed projecting from dorsal aspect of sacrum.
6. Function: It gives strength to pelvic girdle,

ii. Coccyx:

1. It is a triangular bone which is formed by fusion of four coccygeal vertebrae.
2. It is reduced and does not show vertebral foramina and spinous processes.
3. The transverse processes of coccygeal vertebrae are reduced.

Question 36.
Identify the given vertebrae and label it.

Answer:

Question 37.
Describe in brief the structure of thoracic cage.
Answer:
Thoracic cage consists of 12 pairs of ribs, breast bone or sternum.

i. Ribs:

1. A rib is a ‘C’ shaped bone. It is attached to respective thoracic vertebrae on dorsal side.
2. Twelve pairs of ribs are attached to twelve thoracic vertebrae. For attachment to the vertebrae the posterior ends of ribs have two protuberances namely the head and tubercle.
3. The head of rib attaches to facet formed by demifacets of adjacent thoracic vertebrae at the base of transverse processes.
   
4. The tip of transverse processes of these vertebrae also have facets for attachment of ribs where tubercles of ribs are attached.
5. Ribs provide space for attachment of intercostal muscles.
6. On ventral side, the ribs may or may not attach the sternum. Depending on their attachment, the ribs are classified into three types:
   1. True ribs: First seven pairs of ribs are attached directly to the sternum by means of their costal cartilages.
   2. False ribs: Costal cartilages of rib numbers 8, 9 and 10 are attached to rib number 7 on either side and not directly to the sternum. Hence, these are called false ribs.
   3. Floating ribs: Last two pairs of ribs have no ventral connection. Hence, they are called floating ribs.

ii. Sternum:

1. It is a flat, narrow bone, around 15 cms in length.
   
2. It is placed medially in anterior thoracic ] jugular notch wall (chest region).
3. It consists of three distinct parts – manubrium, body and xiphoid processes.
4. Manubrium shows two notches on anterio-lateral side for attachment with clavicle of each side. It also shows two notches on each of the lateral side for attachment of first two pairs of ribs.
5. Body of sternum is a flat bone that shows five notches on lateral aspect which are meant for direct or indirect attachment of ribs.
6. Xiphoid process is lowermost part of sternum which is initially cartilaginous and gets ossified in adults. It provides space for the attachment of diaphragm and abdominal muscles.
7. Ribs are attached to sternum by means of cartilaginous extensions called costal cartilages.

Question 38.
What is intercostal space?
Answer:
The space between the ribs is called as intercostal space.

Question 39.
Describe the bones of pectoral girdle.
Answer:

Pectoral girdle is called as shoulder girdle. It attaches forelimb skeleton with axial skeleton. There are two pectoral girdles, each consists of a shoulder blade or scapula and collar bone or clavicle.

i. Clavicle:

1. It is a ‘S’ shaped slender bone.
2. One end of clavicle is attached to acromion process of scapula. The other rounded end called sternal end attaches to manubrium of sternum.
3. This connects upper arm skeleton to axial skeleton.

ii. Scapula:

1. It is a large, flat, triangular bone that occupies posterior chest wall extending from 2nd to 7th ribs.
2. It is attached to axial skeleton by muscles and tendons.
3. Scapula bears a concave socket called glenoid cavity at its lateral angle.
4. Head of humerus (the upper arm bone) fits into the glenoid cavity.
5. A beak like coracoid process projects from lateral angle of scapula and acromion process arise from scapula. They can be easily felt as high point of shoulder. Both the processes are meant for attachment of muscles.

Question 40.
Describe the bones of forelimb.
Answer:
Forelimb consists of humerus, radius and ulna (together forming forearm bones), carpals (bones of wrist), metacarpals (bones of palm) and phalanges (bones of digits). It consists of 30 bones.

i. Humerus:

1. This is the bone of upper arm.
2. It has a hemispherical head at its proximal end. On either side of head of humerus are present a pair of projections termed greater and lesser tubercles.
   
3. Bicipital groove is a deep groove present between the tubercles where a tendon of biceps muscle is attached.
4. The shaft of humerus shows deltoid tuberosity. Distal end of humerus shows pulley like part called trochlea that articulates with ulna.

ii. Radius and Ulna:

1. Radius is located laterally on thumb side of the forearm.
2. The proximal end of radius has disc like head that articulates with humerus bone.
3. The shaft of radius widens distally to form styloid process.
4. Ulna is located medially on little finger side of forearm.
5. At the proximal end of ulna there is a prominent process called Olecranon process that forms elbow joint with humerus bone. On the lateral side, near the upper end of ulna is present the radial notch into which the side of head of radius is fixed.
   
   f. Radius and ulna articulate with each other at upper and lower extremities by superior and inferior radio-ulnar joints. In between the shaft of two bones, interosseous membrane is present.

iii. Carpals: These are bones of wrist, arranged in two rows of four each.

iv. Metacarpals: Five elongated metacarpals form the bones of palm. Their proximal ends join with carpals and distal ends form knuckles.

v. Phalanges: Phalanges form the bones of fingers and thumb. There are 14 phalanges in each hand (Four fingers have three phalanges each and thumb has two).

Question 41.
Explain briefly the pelvic girdle with a neat and labelled diagram.
Answer:

1. Pelvic girdle also known as hip girdle connects hind limb skeleton with axial skeleton.
2. It is made up of two hip bones called coxal bones. These coxal bones unite posteriorly with sacrum.
3. Coxal bone is a large irregularly shaped bone is made up of three parts – ilium, ischium and pubis.
4. At the point of fusion of ilium, ischium and pubis, a cavity called acetabulum is present that forms ball and socket joint with the thigh bone.
   
5. The two pubis bones are joined medially by cartilaginous joint called pubic symphysis. Pubis and ischium together form a ring of bone that encloses a space called obturator foramen.

Question 42.
Describe the bones of lower limb.
Answer:
The bones of lower limb are femur, patella, tibia and fibula, tarsals, metatarsals and phalanges.

i. Femur: The thigh bone is the longest bone in the body. The head is joined to shaft at an angle by a short neck. It forms ball and socket joint with acetabulum cavity of coxal bone. The lower one third region of shaft is triangular flattened area called popliteal surface. Distal end has two condyles that articulate with tibia and fibula.

ii. Patella: It is also called as knee cap. ft is a sesamoid bone (bone embedded in tendon). It is a flat rounded bone with a pointed lower end.

iii. Tibia and fibula: These are the two long bones of shank or lower leg. The two bones are connected to each other at the extremities. In between the two bones interosseous membrane is present.

1. Tibia: It is much thicker and stronger than fibula. Its broad and expanded upper end articulates with femur and the lower end articulates with talus (tarsal bone).
2. Fibula: It is a long slender bone on lateral side of tibia.
   

iv. Tarsals: These are the bones of ankle. Seven tarsals are arranged in three rows, two proximal, one intermediate and four distal.

v. Metatarsals: Five metatarsal bones support the foot. Proximally they attach with distal row of tarsals and distally the metatarsals articulate with phalanges.

vi. Phalanges: These are the bones of the toes. Except the big toe which has two phalanges, the other four toes have three phalanges each.

Question 43.
What is arthrology?
Answer:
The study of joints is called arthrology.

Question 44.
What makes synovial joint freely movable?
Answer:
Synovial joint is characterised by synovial cavity between the articulating bones which allows free movement at the joint. This makes the joint freely movable.

Question 45.
Complete the given table.

Answer:

Question 46.
State and explain the disorders related to muscles.
Answer:
i. Muscular dystrophy:

1. It is a gradual wasting disease affecting various groups of muscles.
2. It is a genetic disorder.
3. Usually the voluntary skeletal muscles are weakened whereas internal muscles such as diaphragm are not affected in the patient suffering from this disorder.
4. The Duchenne type of muscular dystrophy usually occurs in boys, affecting their lower limbs.
5. Limb girdle muscular dystrophy affects the muscles of shoulders or hips and it usually starts in adults between 20 – 30 years.
6. There is no cure for this disease.

ii. Myasthenia gravis:

1. It is a weakness of skeletal muscles.
2. It is caused by an abnormality at the neuromuscular junction that partially blocks muscle contraction.
3. It is an autoimmune disorder caused by excessive production of certain antibodies in the blood stream. These antibodies bind to acetylcholine receptors of neuromuscular junction. Thus, the transmission of nerve impulses to the muscle fibres is blocked. This causes progressive and extensive muscle weakness.
4. It may affect the eye and eyelid movements, facial expression and swallowing.
5. The degree of muscle weakness varies from local to general.
6. Symptoms: Ptosis (drooping or falling of upper eye lid), diplopia or double vision, difficulty in swallowing, chewing and speech.

Question 47.
Give an account on disorders related to bones.
Answer:

1. Arthritis: It is an inflammation of joints. It is a painful disorder of bones, ligaments, tendons, etc. In this disorder, joints become swollen, stiff and painful. It can lead to disability.
2. Arthritis is of three types:
   1. Osteoarthritis: In this disorder, the joint cartilage is degenerated. It is caused by various factors like aging, obesity, muscle weakness, etc. This is the most common type of arthritis that affects hands, knees and spine.
   2. Gouty arthritis (Gout): In this disorder, joint pain occurs due to the deposition of uric acid in joints. If uric acid is produced in excess or is not excreted, it accumulates in joints as sodium urate. The accumulated sodium urate degenerates the cartilage causing inflammation and pain. It generally affects the joints of feet.
   3. Rheumotoid arthritis: It is an autoimmune disorder where body’s immune system attacks its own tissues. In rheumatoid arthritis, synovial membrane swells up and starts secreting extra synovial fluid. This fluid exerts pressure on joint and makes it painful. Membrane may develop abnormal granulation tissue called pannus. Pannus may erode cartilage. Fibrous tissue gets ossified and may lead to stiffness in joints.
3. Osteoporosis:
   1. In this disorder, bones become porous and hence brittle. It is primarily age related disease and is more common in women than men.
   2. As age advances, bone resorption outpaces bone formation. Hence, the bones lose mass and become brittle. More calcium is lost in urine, sweat, etc., than it is gained through diet. Thus, prevention of disease is better than treatment by consuming adequate amount of calcium and exercise at young age.
   3. Osteoporosis may be caused due to decreasing estrogen secretion after menopause, deficiency of vitamin D, low calcium diet, decreased secretion of sex hormones and thyrocalcitonin.

Question 48.
Name the following.

Question 1.
The striated muscles that are known as prime movers
Answer:
Agonists

Question 2.
The antagonistic muscles that lower the body part
Answer:
Depressor

Question 3.
The contractile proteins of sarcomere
Answer:
Actin and myosin

Question 4.
Sliding filament theory is also known as
Answer:
Walk along theory or Rachet theory

Question 5.
The smallest facial bone
Answer:
Lacrimal bones

Question 6.
Number of bones in thoracic cage
Answer:
25

Question 7.
The first cervical vertebrae
Answer:
Atlas

Question 8.
The three bones of pelvic girdle
Answer:
Ilium, ischium and pubis

Question 9.
The bone which is known as the knee cap
Answer:
Patella

Question 10.
Age related disorder more common in woman than man.
Answer:
Osteoporosis

Question 49.
Fill in the blanks.

Question 1.
The actin filament contains two additional proteins strands that are polymers of ___ molecules.
Answer:
tropomyosin

Question 2.
___ of sarcoplasmic reticulum release large number of Ca⁺⁺ into sarcoplasm.
Answer:
Transverse (T) tubules

Question 3.
The joint between the first vertebra and occipital condyle of skull is an example of ____ class of lever.
Answer:
Class I

Question 4.
Endoskeleton of an adult human consists of ___ bones.
Answer:
206

Question 5.
___ are the bones that connect limbs to the axial skeleton.
Answer:
Girdles

Question 6.
___ bones form the roof of cranium.
Answer:
Parietal

Question 7.
Zveomatic bone is commonly known as ___ bone.
Answer:
Cheek

Question 8.
The largest and strongest facial bone is ___
Answer:
Mandible

Question 9.
There are ___ types of vertebrae.
Answer:
5

Question 10.
___ is also known as shoulder girdle.
Answer:
Pectoral girdle

Question 11.
___ are the bones of wrist.
Answer:
Carpals

Question 12.
___ is known as immovable or fixed joint.
Answer:
Synarthroses

Question 13.
Tibia and fibula are two long bones of ___.
Answer:
Shank or lower leg

Question 14.
___ is caused due to deposition of uric acid in joints.
Answer:
Gouty arthritis

Question 50.
State whether the following statements are True or False:

Question 1.
Saggital suture joins frontal bone with parietal bone.
Answer:
False. Saggital suture joins two parietal bones.

Question 2.
In human beings, there are 10 pairs of ribs.
Answer:
False. In human beings, there are 12 pairs of ribs.

Question 3.
Hyoid bone does not articulate with any other bone.
Answer:
True

Question 4.
Pivot joint is present between Atlas and Axis vertebrae.
Answer:
True

Question 5.
The two pubis bones are joined by cartilaginous joint called pubic symphysis.
Answer:
True

Question 6.
Rheumatoid arthritis is an autoimmune disorder.
Answer:
True

Question 50.
Identify the INCORRECTLY labelled part of pectoral girdle.

Answer:
Glenoid cavity is incorrectly labelled as obturator foramen.

Multiple Choice Questions

Question 1.
Locomotion in sperms takes place with the help of
(A) flagella
(B) cilia
(C) pseudopodia
(D) muscles
Answer:
(A) flagella

Question 2.
Levator muscles result into the action of
(A) lowering a body part
(B) tensing a body part
(C) relaxing a body part
(D) raising a body part
Answer:
(D) raising a body part

Question 3.
Which of these is not a skull bone?
(A) Frontal
(B) Scapula
(C) Occipital
(D) Temporal
Answer:
(B) Scapula

Question 4.
Immovable joint is in between the bones of
(A) frontal and parietal
(B) metacarpal and phalangeal
(C) femur and tibia
(D) radius and ulna
Answer:
(A) frontal and parietal

Question 5.
Total number of vertebrae in human beings is
(A) 22
(B) 33
(C) 24
(D) 12
Answer:
(B) 33

Question 6.
Which of the following is NOT a part of appendicular skeleton?
(A) Girdles
(B) Forelimb
(C) Hindlimb
(D) Vertebral column
Answer:
(D) Vertebral column

Question 7.
___ connects the upper arm to the axial skeleton.
(A) Clavicle
(B) Patella
(C) Tibia
(D) Femur
Answer:
(A) Clavicle

Question 8.
__ is a part of hind limb.
(A) Radius
(B) Ulna
(C) Humers
(D) Fibula
Answer:
(D) Fibula

Question 9.
Which of the following are toe bones?
(A) Tarsals
(B) Metatarsals
(C) Carpals
(D) Phalanges
Answer:
(D) Phalanges

Question 10.
Sutures on the skull are ___ joints.
(A) freely movable
(B) slightly movable
(C) fixed
(D) synovial
Answer:
(C) fixed

Question 11.
___ is an example of syndesmoses.
(A) Distal tibiofibular joint
(B) Rib-sternum junction
(C) Tooth and jaw bones
(D) Intervertebral disc
Answer:
(A) Distal tibiofibular joint

Question 12.
Elbow joint is
(A) ball and socket joint
(B) hinge joint
(C) suture joint
(D) gliding joint
Answer:
(B) hinge joint

Question 13.
Complete the analogy.
Hinge joint: Monoaxial movement:: ___ Biaxial movement
(A) Ball and socket joint
(B) Gliding joint
(C) Condyloid joint
(D) Both (A) and (B)
Answer:
(C) Condyloid joint

Question 14.
An autoimmune disorder in which an antibody reduces the efficiency of transmission between the motor neuron is called
(A) Myasthenia gravis
(B) Tetany
(C) Osteoarthritis
(D) Osteoporosis
Answer:
(A) Myasthenia gravis

Balbharti Maharashtra State Board 11th Biology Important Questions Chapter 15 Excretion and Osmoregulation Important Questions and Answers.

Maharashtra State Board 11th Biology Important Questions Chapter 15 Excretion and Osmoregulation

Question 1.
What are metabolic waste products?
Answer:
Metabolism produces a variety of by-products, some of which need to be eliminated. Such by-products are called metabolic waste products.

Question 2.
Define excretion.
Answer:
The process of eliminating waste products from the body is called excretion.

Question 3.
Where are metabolic wastes produced?
Answer:
Metabolic wastes are produced inside body cells.

Question 4.
Enlist the various excretory products produced in the human body.
Answer:
The various excretory products produced by the human body are as follows:

1. Fluids such as water; gaseous wastes like CO₂; nitrogenous wastes like ammonia, urea and uric acid, creatinine; minerals; salts of sodium, potassium, calcium, etc. if present in body in excess are excreted through urine, faeces and sweat.
2. Pigments formed due to breakdown of haemoglobin like bilirubin (excreted through faeces) and urochrome (eliminated through urine).
3. The pigments present in consumed foodstuffs like beet root or excess of vitamins, hormones and drugs.
4. Volatile substances present in spices (eliminated through lungs).

Question 5.
Write a note on deamination.
Answer:

1. Deamination is the process of breakdown of excess amino acids.
2. It is an essential process, since the body of an organism is unable to store excess amino acids.
3. In this process, amino group is separated from the amino acid and ammonia is formed.
4. Toxic ammonia is either excreted or converted to less toxic forms like urea or uric acid before excretion.

Question 6.
Availability of water plays a key role in deciding the mode of excretion of an organism. Justify.
Answer:

1. Ammonia is the basic product of deamination process.
2. Ammonia is highly toxic and needs to be diluted immediately.
3. If there is no or limited access to water, need for conversion of ammonia becomes necessary.
   Hence, the availability of water plays a key role in deciding the mode of excretion of an organism.

Question 7.
What are the three main modes of excretion in animals?
Answer:
The three main modes of excretion in animals are as follows:
i. Ammonotelism
ii. Ureotelism
iii. Uricotelism

1. Ammonotelism:
   • Elimination of nitrogenous wastes in the form of ammonia is called as ammonotelism.
   • Ammonia is basic in nature and hence it can disturb the pH of the body, if not eliminated immediately.
   • Any change in pH would disturb all enzyme catalyzed reactions in the body and would also make the plasma membrane unstable.
   • Ammonia is readily soluble in water and needs large quantity of water to dilute and reduce its toxicity.
   • This is however an energy saving mechanism of excretion and hence all animals that have plenty of water available for dilution of ammonia, excrete nitrogenous wastes in the form of ammonia.
   • Animals that follow this mode of excretion are known as ammonotelic animals.
   • 1 gm ammonia needs about 300 – 500 ml of water for elimination.
   • Ammonotelic animals excrete ammonia through general body surface (skin), gills and kidneys.
     e.g. Ammonotelism is found in aquatic invertebrates, bony fishes, and aquatic / larval amphibians. Animals without excretory system (Protozoa) are also ammonotelic.
2. Ureotelism:
   • Elimination of nitrogenous wastes in the form of urea is called as ureotelism.
   • Urea is comparatively less toxic and less water-soluble than ammonia. Hence, it can be concentrated to some extent in body.
   • The body requires less water for elimination.
   • Since it is less toxic and less water soluble, ureotelism is suitable for animals that need to conserve water to some extent. Hence, ureotelism is common in terrestrial animals, as they have to conserve water.
   • It takes about 50 ml H2O for removal of 1 gm NH2 in form of urea.
   • Ureotelic animals generally convert ammonia to urea in the liver by operating ornithine / urea cycle in which 3 ATP molecules are used to produce one molecule of urea.
     e.g. Mammals, cartilaginous fishes (sharks and rays), many aquatic reptiles, most of the adult amphibians, etc. are ureotelic.
3. Uricotelism:
   • Elimination of nitrogenous wastes in the form of uric acid is called as uricotelism.
   • Uric acid is least toxic and hence, it can be retained in the body for some time in concentrated form.
   • It is least soluble in water. Hence there is minimum (about 5 – 10 ml for 1 gm) or no need of water for its elimination.
   • Those animals which need to conserve more water follow uricotelism. However, these animals need to spend more energy.
   • Ammonia is converted into uric acid by ‘inosinic acid pathway’ in the liver of birds, e.g. Birds, some insects, many reptiles, land snails, are uricotelic.

Question 8.
Fill in the blanks:
i. ________ is the basic product of deamination process.
ii. Aquatic amphibians excrete nitrogenous waste in the form of _______.
iii. Uricotelic organisms, convert ammonia to urea in the _______ by operating _____ cycle.
iv. Ammonia is converted into uric acid by ______ pathway in birds.
Answer:
i. Ammonia
ii. Ammonia
iii. liver, omithine/urea
iv. inosinic acid

Question 9.
Explain the following sentences,
i. Humans are ureotelic.
Answer:

• Urea is comparatively less toxic and less water – soluble than ammonia. Hence, it can be concentrated to some extent in the body.
• The body requires less water for elimination of urea.
  c. Due to these properties, ureotelism is suitable for animals which need to conserve water to some extent.
  Thus, humans are ureotelic.

ii. Sharks retain more urea in their blood.
Answer:

• Sharks retain more urea in their body fluid (blood) to make their blood isotonic to surrounding marine water (in order to maintain osmotic balance).
• This helps them to prevent possible loss of water by exosmosis.

Question 10.
Distinguish between Ureotelism and Uricotelism.
Answer:

Question 11.
Distinguish between Ammonotelism and Uricotelism.
Answer:

Question 12.
Terrestrial animals are generally either ureotelic or uricotelic, not ammonotelic. Why?
Answer:

1. Ammonia is highly toxic to animals.
2. An animal requires large amount of water to dissolve and eliminate ammonia.
3. Terrestrial animals cannot lose such a large amount of water.
4. Ureotelic and uricotelic animals require less amount of water for removal of nitrogenous waste. Hence, to conserve water, ureotelism and uricotelism is adapted by terrestrial animals.

Question 13.
What is plasma creatinine? Why is it used as an index of kidney function?
Answer:

1. Plasma creatinine is produced from catabolism of creatinine phosphate during skeletal muscle contraction.
2. It provides a ready source of high energy phosphate.
3. Normally blood creatinine levels remain steady because the rate of production matches its excretion in urine.
4. Hence, plasma creatinine is used as an index of kidney function and its level above normal is an indication of poor renal function.
   [Note: Plasma creatinine is a waste product produced by muscles from the breakdown of a compound called ‘creatine phosphate.]

Question 14.
How can excretion play a role in homeostasis?
Answer:

1. Homeostasis is the maintenance of constant internal environment of the body.
2. Homeostasis is however dependent on osmoregulation, which is the process of controlling solute concentrations and water balance.
3. The composition of blood and therefore the internal environment is highly dependent on what the excretory organs retain in the body.
   Hence, excretion plays an important role in homeostasis.

Question 15.
How do different organisms carry out excretion?
Answer:
Different organisms carry out excretion in the following manner:

1. Unicellular organisms have contractile vacuoles which collect and discharge waste products outside the cell.
2. Excretion in sponges takes place by diffusion of waste material in water. This waste is discharged through the osculum.
3. True organs of excretion are found in those animals that show bilateral symmetry.
4. The most common type of excretory organ is a simple or branching tube that opens to the exterior, through pores called nephridiopores. This system is generally found in some annelids, Amphioxus, earthworms, etc.
5. In most of the insects, excretion takes place by a set of blind ended tubules called malpighian tubules.
6. Crustaceans have green glands as excretory organs.
7. Members of phylum Echinodermata do not have any specialised excretory organs. Waste materials directly diffuse into water or are excreted through tube feet.
8. The mammalian kidneys are a collection of functional units called nephrons, which are well designed to excrete metabolic waste.

Question 16.
What are nephridia? Explain the major types of nephridia in detail.
Answer:
Nephridia are simple or branching tubules used for excretion which open to the exterior through pores called nephridiopores.
Two major types of nephridia are as follows:
i. Protonephridia:
These are network of dead end tubes called flame cells. They are mostly found in animals that lack a true body cavity, e.g. Platyhelminthes, rotifers, some annelids and Amphioxus.

ii. Metanephridia:
These are unbranched coiled tubes that are connected to the body cavity through funnel like structures called nephrostomes. Body fluid enters the nephridium through nephrostome and gets discharged ‘ through nephridiopore. e.g. Earthworms.

Question 17.
Distinguish between the Ureter and Urethra.
Answer:

Question 18.
Write a short note on micturition.
Answer:

1. The process of release of urine from the urinary bladder is called micturition.
2. The average capacity of urinary bladder is 700 ml.
3. When urinary bladder is almost half filled, stretch receptors in urinary bladder transmit impulses to spinal cord, initiating a conscious desire to expel urine.
4. Micturition reflex center of spinal cord transmit impulses to the wall of urinary bladder and internal urethral sphincter.
5. Bladder muscles contract and muscles of internal urethral sphincter relax.
6. The external sphincter receives impulses from conscious centre of brain and relaxes.
7. This leads to elimination of urine from the bladder.

Question 19.
Explain the L.S of kidney with a neat and labelled diagram.
Answer:

1. Each kidney is covered by three layers of tissue, namely the outermost renal fascia, middle adipose capsule and innermost renal capsule.
   • The outermost layer, renal fascia is made up of a thin layer of fibrous connective tissue. It anchors the kidney to the abdominal wall as well as surrounding tissue.
   • The middle layer is a mass of fatty tissue called adipose capsule. It protects the kidneys by shock absorption.
   • The innermost layer, renal capsule is a smooth transparent fibrous membrane that is continuous with outer layer of ureters. It acts as a barrier against spread of infections in kidney.
2. The L.S. of kidney shows two distinct regions within the capsule. Histologically, kidney is divisible into two regions as renal cortex and renal medulla.
   • Renal cortex is the outer / peripheral, red coloured and granular region. It contains Malpighian bodies, convoluted tubules and blood vessels.
   • Medulla is inner region of kidney with pale red colour and striated appearance. Medulla mainly consists of Loops of Henle and collecting ducts. All these are arranged in conical manner to form renal pyramids.
   • Cortex extends in medulla as columns of Bertini / renal columns between pyramids. Narrow tip of pyramid is called as renal papilla. There are several pyramids.
   • Renal papilla open into the minor calyx. Minor calyces merge together to form major calyces and major calyces unite together to form renal pelvis.
   • Renal pelvis (renal sinus) is funnel-shaped area in the region of medulla of kidney. Renal pelvis
     

Question 20.
What is nephrology?
Answer:
Nephrology is branch of biology that deals with the structure, function and disorders of male and female urinary system.

Question 21.
Write a note on nephron.
Answer:

1. Nephrons are structural and functional units of kidney.
2. Each nephron consists of a 4 – 6 cm long, thin-walled tube called the renal tubule and a bunch of capillaries known as the glomerulus.
3. The wall of the renal tubule is made up of a single layer of epithelial cells.
4. Its proximal end is wide, blind, cup-like and is called as Bowman’s capsule, whereas the distal end is open.
5. The nephron is divisible into Bowman’s capsule, neck, proximal convoluted tubule (PCT), Loop of Henle (LoH), distal convoluted tubule (DCT) and collecting tubule (CT).
6. The glomerulus is present in the cup-like cavity of Bowman’s capsule and both are collectively known as renal corpuscle or Malpighian body.

Question 22.
With the help of a well labelled diagram, describe the structure of nephron.
Answer:
Nephron is the structural and functional unit of kidney.
Structure of nephron:
A nephron (uriniferous tubule) is a thin walled, coiled duct, lined by a single layer of epithelial cells. Each nephron is divided into two main parts:
i. Malpighian body
ii. Renal tubule

i. Malpighian body: Each Malpighian body is about 200pm in diameter and consists of a Bowman’s capsule and glomerulus.
a. Glomerulus:
Glomerulus is a bunch of fine blood capillaries located in the cavity of Bowman’s capsule.
A small terminal branch of the renal artery, called as afferent arteriole enters the cup cavity (Bowman capsule) and undergoes extensive fine branching to form network of several capillaries. This bunch is called as glomerulus.
The capillary wall is fenestrated (perforated).
All capillaries reunite and form an efferent arteriole that leaves the cup cavity.
The diameter of the afferent arteriole is greater than the efferent arteriole. This creates a high hydrostatic pressure essential for ultrafiltration, in the glomerulus.

b. Bowman’s capsule:
It is a cup-like structure having double walls composed of squamous epithelium.
The outer wall is called as parietal wall and the inner wall is called as visceral wall.
The parietal wall is thin consisting of simple squamous epithelium.
There is a space called as capsular space / urinary space in between two walls.
Visceral wall consists of special type of squamous cells called podocytes having a foot-like pedicel. These podocytes are in close contact with the walls of capillaries of glomerulus.
There are small slits called as filtration slits in between adjacent podocytes.

ii. Renal tubule:
a. Neck:
The Bowman’s capsule continues into the neck. The wall of neck is made up of ciliated epithelium. The lumen of the neck is called the urinary pole. The neck leads to proximal convoluted tubule.

b. Proximal Convoluted Tubule :
This is highly coiled part of nephron which is lined by cuboidal cells with brush border (microvilli) and surrounded by peritubular capillaries. Selective reabsorption occurs in PCT. Due to convolutions (coiling), filtrate flows slowly and remains in the PCT for longer duration, ensuring that maximum amount of useful molecules are reabsorbed.

c. Loop of Henle :
This is ‘U’ shaped tube consisting of descending and ascending limb.
The descending limb is thin walled and permeable to water and lined with simple squamous epithelium.
The ascending limb is thick walled and impermeable to water and is lined with simple cuboidal epithelium.
The LoH is surrounded by capillaries called vasa recta.
Its function is to operate counter current system – a mechanism for osmoregulation.
The ascending limb of Henle’s loop leads to DCT.

d. Distal convoluted tubule:
This is another coiled part of the nephron.
Its wall consists of simple cuboidal epithelium.
DCT performs tubular secretion / augmentation / active secretion in which, wastes are taken up from surrounding capillaries and secreted into passing urine.
DCT helps in water reabsorption and regulation of pH of body fluids.

e. Collecting tubule:
This is a short, straight part of the DCT which reabsorbs water and secretes protons.
The collecting tubule opens into the collecting duct.

Question 23.
What is the difference between Cortical nephrons and Juxtamedullary nephrons.
Answer:

Question 24.
Sketch and label Malpighian body.
Answer:

Question 25.
What are podocytes? In which part of the nephron are they present?
Answer:
Podocytes are a special type of squamous cells that have a foot-like pedicel. They are present in the visceral wall of the Bowman’s capsule and are in close contact with the walls of capillaries of glomerulus

Question 26.
Write a short note on Juxta Glomerular Apparatus.
Answer:

1. Some smooth muscle cells of the wall of afferent arteriole are modified in such a way that their sarcoplasm is granular. These cells are called juxtaglomerular (JG) cells.
2. In each nephron, initial part of DCT makes contact with the afferent arteriole of same nephron.
3. Cells in the wall of DCT in this region are packed more densely than those in other region of DCT. This is called macula densa.
4. Macula densa and the JG cells together form Juxta Glomerular Apparatus (JGA).
5. The JGA plays an important role in blood pressure regulation within the kidney.

Question 27.
Explain the mechanism of urine formation in detail.
Answer:
Process of urine formation is completed in three steps, namely;
i. Ultrafiltration/ Glomerular filtration,
ii. Selective reabsorption,
iii. Tubular secretion / Augmentation

i. Ultrafiltration / Glomerular filtration :
Diameter of afferent arteriole is greater than the efferent arteriole. The diameter of capillaries is still smaller than both arterioles. Due to the difference in diameter, blood flows with greater pressure through the glomerulus. This is called as glomerular hydrostatic pressure (GHP) and normally, it is about 55 mmHg. GIIP is opposed by osmotic pressure of blood (normally, about 30 mm Hg) and capsular pressure (normally, about 15 mm Hg).

Hence net / effective filtration pressure (EFP) is 10 mm Hg.
EFP = Hydrostatic pressure in glomerulus – (Osmotic pressure of blood + Filtrate Hydrostatic pressure)
= 55 – (30 +15)
= 10 mm Hg

Under the effect of high pressure, the thin walls of the capillary become permeable to major components of blood (except blood cells and macromolecules like protein).
Thus, plasma except proteins oozes out through wall of capillaries.
About 600 ml blood passes through each kidney per minute.

The blood (plasma) flowing through kidney (glomeruli) is filtered as glomerular filtrate, at a rate of 125 ml / min. (180 L/d).

Glomerular filtrate / deproteinized plasma / primary urine is alkaline, contains urea, amino acids, glucose, pigments, and inorganic ions.

Glomerular filtrate passes through filtration slits into capsular space and then reaches the proximal convoluted tubule.

ii. Selective reabsorption :
Selective reabsorption occurs in proximal convoluted tubule (PCT). It is highly coiled so that glomerular filtrate passes through it very slowly. Columnar cells of PCT are provided with microvilli due to which absorptive area increases enormously.

This makes the process of reabsorption very effective.
These cells perform active (ATP mediated) and passive (simple diffusion) reabsorption.
Substances with considerable importance (high threshold) like – glucose, amino acids, vitamin C, Ca⁺⁺, K⁺, Na⁺, Cl^– are absorbed actively, against the concentration gradient. Low threshold substances like water, sulphates, nitrates, etc., are absorbed passively.
In this way, about 99% of glomerular filtrate is reabsorbed in PCT and DCT.

iii. Tubular secretion / Augmentation :
Finally filtrate reaches the distal convoluted tubule via loop of Henle. Peritubular capillaries surround DCT. Cells of distal convoluted tubule and collecting tubule actively absorb the wastes like creatinine and ions like K⁺, H⁺ from peritubular capillaries and secrete them into the lumen of DCT and CT, thereby augmenting the concentration of urine and changing its pH from alkaline to acidic.

Secretion of H⁺ ions in DCT and CT is an important homeostatic mechanism for pH regulation of blood. Tubular secretion is the only process of excretion in marine bony fishes and desert amphibians.

Question 28.
Marine bony fishes and desert amphibians rely on which process of excretion?
Answer:
Tubular secretion

Question 29.
Where does selective reabsorption of glomerular filtrate take place?
Answer:
Selective reabsorption of glomerular filtrate takes place in the proximal convoluted tubule (PCT).

Question 30.
What is glomerular filtration pressure or net effective filtration pressure?
Answer:
Glomerular filtration pressure (GFP)/ Effective filtration pressure (EFP) is the difference between the hydrostatic pressure (GHP) and the sum of osmotic pressure of blood and capsular pressure (CHP).
It can be represented as:
EFP = Glomerular hydrostatic pressure – (Osmotic pressure of blood + Filtrate Flydrostatic pressure)
= 55 – (30 + 15)
= 10 mmHg
[Note: Net filtration pressure = Glomerular blood hydrostatic pressure – (Capsular hydrostatic pressure + Blood colloid osmotic pressure)
Source: Tort or a, G., Derrickson, B. Principles of Anatomy and Physiology. 11^th Edition.]

Question 31.
Distinguish between Selective reabsorption and Tubular secretion.
Answer:

Question 32.
Explain the process of concentration of urine in deai1.
OR
Explain counter current mechanism in detail.
Answer:
Under the conditions like low water intake or high water loss due to sweating, humans can produce concentrated urine. This urine can be concentrated around four times i.e. 1200 mOsm/L, than the blood (300 mOsm/L). hence, a mechanism called countercurrent mechanism is operated in the human kidneys. The countercurrent mechanism operating in the Limbs of Henle’s loop of juxtamedullarv nephrons and vasa recta is as follows:
i. It involves the passage of fluid from descending to ascending limb of Henle’s loop.

ii. This mechanism is called countercurrent mechanism, since the flow of tubular fluid is in opposite direction through both limbs.

iii. In case of the vasa recta, blood flows from ascending to descending parts of itself.

iv. Wall of descending limb is thin and permeable to water, hence, water diffuses from tubular fluid into tissue fluid due to which, tubular fluid becomes concentrated.
v. The ascending limb is thick and impermeable to water. Its cells can reabsorb Na⁺ and Cl^– from tubular fluid and release into tissue fluid.

vi. Due to this, tissue fluid around descending limb becomes concentrated. This makes more water to move out from descending limb into tissue fluid by osmosis.

vii. Thus, as tubular fluid passes down through descending limb, its osmolarity (concentration) increases gradually due to water loss and on the other hand, progressively decreases due to Na⁺ and Cl^– secretion as it flows up through ascending limb.

viii. Whenever retention of water is necessary, the pituitary secretes ADH. ADH makes the cells in the wall of collecting ducts permeable to water.

ix. Due to this, water moves from tubular fluid into tissue fluid, making the urine concentrated.

x. Cells in the wall of deep medullar part of collecting ducts are permeable to urea. As concentrated urine flows through it, urea diffuses from urine into tissue fluid and from tissue fluid into the tubular fluid flowing through thin ascending limb of Henle’s loop.

xi. This urea cannot pass out from tubular fluid while flowing through thick segment of ascending limb, DCT and cortical portion of collecting duct due to impermeability for it in these regions.

xii. However, while flowing through collecting duct, water reabsorption is operated under the influence of ADII. Due to this, urea concentration increases in the tubular fluid and same urea again diffuses into tissue fluid in deep medullar region.

xiii. Thus, same urea is transferred between segments of renal tubule and tissue fluid of inner medulla. This is called urea recycling; operated for more and more water reabsorption from tubular fluid and thereby excreting small volumes of concentrated urine.

xiv. Osmotic gradient is essential in the renal medulla for water reabsorption by counter current multiplier system.

xv. This osmotic gradient is maintained by vasa recta by operating counter current exchange system.

xvi. Vasa recta also have descending and ascending limbs. Blood that enters the descending limb of the vasa recta has normal osmolarity of about 300 mOsm/L.

xvii. As it flows down in the region of renal medulla where tissue fluid becomes increasingly concentrated, Na⁺, Cl^– and urea molecules diffuse from tissue fluid into blood and water diffuse from blood into tissue fluid.

xviii. Due to this, blood becomes more concentrated which now flows through ascending part of vasa recta. This part runs through such region of medulla where tissue fluid is less concentrated.

xix. Due to this, Na⁺, Cl^– and urea molecules diffuse from blood to tissue fluid and water from tissue fluid to blood. This mechanism helps to maintain the osmotic gradient.

Question 33.
Camel excretes concentrated urine. Give reason.
Answer:
In order to reabsorb water to maximum capacity, loop of Henle is longer in desert mammals like camel. Hence, camel excretes concentrated urine.

Question 34.
Why is urine yellow in colour?
Answer:
Normal urine is pale yellow coloured transparent liquid, due to the pigment urochrome.

Question 35.
How is the composition of urine regulated?
Answer:
The composition of urine depends upon food and fluid consumed by an individual. There are two ways in which it the composition is regulated. They are as follows:

1. Regulating water reabsorption through ADH
2. Electrolyte reabsorption though RAAS
3. Atrial Natriuretic Peptide

i) Regulating water reabsorption through ADH:
Hypothalamus in the midbrain has special receptors called osmoreceptors which can detect change in osmolarity (measure of total number of dissolved particles per liter of solution) of blood.

If osmolarity of blood increases due to water loss from the body (after eating namkeen or due to sweating), osmoreceptors trigger release of Antidiuretic hormone (ADH) from neurohypophysis (posterior pituitary). ADH stimulates reabsorption of water from last part of DCT and entire collecting duct by increasing the permeability of cells.

This leads to reduction in urine volume and decrease in osmolarity of blood.

Once the osmolarity of blood comes to normal, activity of osmoreceptor cells decreases leading to decrease in ADH secretion. This is called negative feedback.

In case of hemorrhage or severe dehydration too, osmoreceptors stimulate ADH secretion. ADH is important in regulating water balance through kidneys.

In absence of ADH, diuresis (dilution of urine) takes place and person tends to excrete large amount of dilute urine. This condition called as diabetes insipidus.
[Note: Hypothalamus is a part of forebrain]

ii) Electrolyte reabsorption through RAAS:
Another regulatory mechanism is RAAS (Renin Angiotensin Aldosterone System) by Juxta Glomerular Apparatus (JGA).

Whenever blood supply (due to change in blood pressure or blood volume) to afferent arteriole decreases (e.g. low BP/dehydration), JGA cells release Renin. Renin converts angiotensinogen secreted by hepatocytes in liver to Angiotensin I. ‘Angiotensin converting enzyme’ further modifies Angiotensin I to Angiotensin II, the active form of hormone. It stimulates adrenal cortex to release another hormone called aldosterone that stimulates DCT and collecting ducts to reabsorb more Na and water, thereby increasing blood volume and pressure.

iii) Atrial natriuretic peptide (ANP):
A large increase in blood volume and pressure stimulates atrial wall to produce atrial natriuretic peptide (ANP). ANP inhibits Na+ and Cl reabsorption from collecting ducts inhibits release of renin, reduces aldosterone and ADH release too. This leads to a condition called Natriuresis (increased excretion of Na+ in urine) and diuresis.

Question 36.
What is renin? Give its function.
Answer:
Renin is an enzyme secreted by juxtaglomerular cells of afferent arteriole.
Function: It activates Angiotensinogen to Angiotensin-I.

Question 37.
What is the function of Angiotensin II?
Answer:
Functions of Angiotensin II:

1. It constricts arterioles in kidney thereby reducing blood flow and increasing blood pressure.
2. It stimulates PCT cells to enhance reabsorption of Na⁺, Cl^– and water.
3. It stimulates adrenal cortex to release another hormone called aldosterone that stimulates DCT and collecting ducts to reabsorb more Na and water, thereby increasing blood volume and pressure.

Question 38.
Which hormones and factors are involved in regulation of kidney function?
Answer:
Hormones like ADH, Renin, Angiotensin and Atrial Natriuretic Peptide (ANP) are involved in regulation of kidney function.

Question 39.
Can improper kidney function lead to brittle bones? Justify your answer.
Answer:
Yes, improper kidney function lead to brittle bones.

1. Kidneys participate in synthesis of calcitriol, the active form of Vitamin D which is needed for absorption of dietary calcium.
2. Deficiency of calcitriol can lead to brittle bones.

Question 40.
Do organs other than kidney participate in excretion? Explain.
Answer:
Yes, various organs other than the kidney participate in excretion. They are as follows:
i. Skin:
Skin acts as an accessory excretory organ. The skin of many organisms is thin and permeable. It helps in diffusion of waste products like ammonia.
Human skin however is thick and impermeable. It shows presence of two types of glands namely, sweat glands and sebaceous glands.
a. Sweat glands are distributed all over the skin. They are abundant in the palm and facial regions. These simple, unbranched, coiled, tubular glands open on the surface of the skin through an opening called sweat pore. Sweat is primarily produced for thermoregulation but it also excretes substances like water, NaCl, lactic acid and urea.
b. Sebaceous glands are present at the neck of hair follicles. They secrete oily substance called sebum. It forms a lubricating layer on skin making it softer. It protects skin from infection and injury.

ii. Lungs:
Lungs are the accessory excretory organs. They help in excretion of volatile substances like C02 and water vapour produced during cellular respiration. Along with CO₂, lungs also remove excess of H₂O in the form of vapours during expiration. They also excrete volatile substances present in spices and other food stuff.

Question 41.
Enlist the human excretory organs and their excretory products.
Answer:
Excretory OrgAnswer:

1. Lungs: Remove CO₂ and also water vapour to a considerable extent. Volatile substances present in spices and other food stuff are excreted through lungs
2. Kidneys: Remove nitrogenous waste products like ammonia, urea and uric acid, creatinine. They also remove excessive amount of water, salts and certain minerals.
3. Skin: Remove water, NaCl, lactic acid and urea by through of sweat.

Question 42.
What is albuminaria? What are its causes?
Answer:

• Albuminaria is the presence of excess albumin in the urine.
• Causes: Injury to the endothelial capsular membrane as a result of increased blood pressure, injury or irritation of kidney cells by substances such as toxins or heavy metals.

Question 43.
A patient report indicates presence of excessive quantities of ketone bodies in the urine. What does this indicate? How is it caused?
Answer:
Presence of excessive quantities of ketone bodies in the urine indicates that the patient is suffering from diabetes mellitus, starvation or too little carbohydrates in the diet.

Question 44.
Sheela is suffering from kidney infection. Presence of which type of cells in the urine can be indicative of this?
Answer:
Presence of leucocytes in the urine can be indicative of infection of kidney or other urinary organs.

Question 45.
Enlist the various disorders and diseases related to the excretory system.
Answer:
Some disorders and diseases related to the excretory system are as follows:

1. Kidney stones
2. Uremia
3. Nephritis
4. Renal Failure
5. Ketonuria
6. Albuminaria

Question 46.
Write a note on kidney stones with reference to types, symptoms and diagnosis.
Answer:
Kidney stones are also called renal calculi. They may be formed in any portion of urinary tract, from kidney tubules to external opening.
Types:
Depending on their composition, kidney stones are classified into the following types.

1. Calcium stones : These are usually calcium oxalate or calcium phosphate stones.
2. Struvite stones : These are formed in response to bacterial infection caused by urea – splitting bacteria. They grow in size quickly and become quite large.
3. Uric acid stones : These stones usually affect people drinking less water or consuming high protein diet.
4. Cystine stones : It is a genetic disorder that causes the kidney to excrete too much of certain amino acid.

Symptoms:
Intermittent pain below rib cage in back and side ways. Hazy, brownish/reddish/ pinkish urine. Frequent urge to pass urine. Pain during micturition.

Diagnosis:
Uric acid content of blood, colour of urine, kidney X-ray, sonography of kidney are different diagnostic tests prescribed depending on symptoms.

Question 47.
What is uremia?
Answer:
If the level of urea in blood rises above 0.05%, the condition is known as uremia. It may lead to kidney failure.

Question 48.
What is the normal content of urea in blood?
Answer:
The normal content of urea in blood is 0.01 to 0.03 %.

Question 49.
Write a note on nephritis.
Answer:

1. Nephritis is the inflammation of kidneys characterised by proteinuria.
2. It is caused due to increased permeability of glomerular capsular membrane, permitting large amounts of proteins to escape from blood to urine.
3. This leads to change in blood colloidal osmotic pressure, leading to movement of fluid from blood to interstitial spaces.
4. It is reflected as edema.

Question 50.
What is renal failure? Describe its types.
Answer:
Renal failure is the decrease or cessation of glomerular filtration and ¡s classified into two types.
i) Acute Renal failure (ARF):
ARF is sudden worsening of renal function that most commonly happens after severe bleeding. There is a decrease in urine output (oligouriaf scanty urine i.e., less than 400 mi/day or less than 0.5 ml/kg/li in children). Other causes of ARF may include acute obstruction of both ureters or nephrotoxic drugs. ARF can be detected biochemically by elevated serum creatinine levels.

ii) Chronic kidney disease (CKD) :
It is the progressive and generally irreversible decline in glomerular filtration rate (GFR). It may be caused due to chronic glomerulonephritis. It can be detected by reduced kidney size and possibility of anaemia.

Question 51.
When does a patient need to undergo haemodialysis? Explain the process in detail.
Answer:

1. When renal function of a person falls below 5 – 7 %, accumulation of harmful substances in blood begins. In such a condition, the person has to go for artificial means of filtration of blood i.e. haemodialysis.
2. In haemodialysis, a dialysis machine is used to filter blood. The blood is filtered outside the body using a dialysis unit.
3. In this procedure, the patients’ blood is removed; generally from the radial artery and passed through a cellophane tube that acts as a semipermeable membrane.
4. The tube is immersed in a fluid called dialysate which is isosmotic to normal blood plasma. Hence, only excess salts if present in plasma pass through the cellophane tube into the dialysate.
5. Waste substances being absent in the dialysate, move from blood into the dialyzing fluid.
6. Filtered blood is returned to vein.
7. In this process it is essential that anticoagulant like heparin is added to the blood while it passing through the tube and before resending it into the circulation, adequate amount of anti-heparin is mixed.
8. Also, the blood has to move slowly through the tube and hence the process is slow.

Question 52.
Write a note on peritoneal dialysis.
Answer:

1. In this method, the dialyzing fluid is introduced in abdominal cavity or peritoneal cavity.
2. The peritoneal membrane acts as semipermeable dialyzing membrane.
3. Toxic wastes and extra solutes pass into the fluid.
4. This fluid is drained out after a prescribed period of time.
5. Peritoneal dialysis can be repeated as per the need of the patient.
6. It can be carried out at home at work or while travelling. But it is not as efficient as haemodialysis.

Question 53.
What are the drawbacks of haemodialysis?
Answer:

• Kidneys are associated with secretion of erythropoietin, renin and calcitriol which is not possible using dialysis machine.
• During dialysis, the blood has to move slowly through the tube and hence the process is slow.

Question 54.
What is kidney transplant?
Answer:

1. It is the organ transplant of a healthy kidney into a patient with end – stage renal disease.
2. Kidney transplantation is classified as cadaveric (deceased donor) or living donor kidney transplant.
3. Living donor kidney transplant are further classified as genetically related (living-related) or non-related (living non-related) transplants.

Question 55.
Complete the diagram / chart with correct labels / information. Write the conceptual details regarding it.
i)

Answer:

Skin:
Skin acts as an accessory excretory organ. The skin of many organisms is thin and permeable. It helps in diffusion of waste products like ammonia.
Human skin however is thick and impermeable. It shows presence of two types of glands namely, sweat glands and sebaceous glands.
a. Sweat glands are distributed all over the skin.
They are abundant in the palm and facial regions. These simple, unbranched, coiled, tubular glands open on the surface of the skin through an opening called sweat pore. Sweat is primarily produced for thermoregulation but it also excretes substances like water, NaCI, lactic acid and urea.

b. Sebaceous glands are present at the neck of hair follicles.
They secrete oily substance called sebum. It forms a Lubricating layer on skin making it softer. It protects skin from infection and injury.

ii)

Answer:

1. In this method, the dialyzing fluid is introduced in abdominal cavity or peritoneal cavity.
2. The peritoneal membrane acts as semipermeable dialyzing membrane.
3. Toxic wastes and extra solutes pass into the fluid.
4. This tluid is drained out after a prescribed period of time.
5. Peritoneal dialysis can be repeated as per the need of the patient.
6. It can be carried out at home at work or while travelling. But it is not as efficient as haemodialysis.

Question 55.
Invertebrates, bony fishes, tadpoles, etc. are ammonotelic. Whereas birds, reptiles, land snails, etc. are uricotelic. What would be the probable reason for the difference in mode of excretion?
i. Ammonotelic organisms conserve water as conversion of ammonia to uric acid requires large amount of water.
ii. Elimination of ammonia requires large quantity of water, thus ammonotelism is seen in aquatic animals.
iii. Uricotelic organisms require moderate water for eliminating urea and formation of ammonia requires expenditure of energy. Thus, to conserve water and energy, these animals have uricotelism mode of excretion.
iv. Aquatic animals can retain ammonia and store it in the body for long time.
(A) i and iii
(B) only ii
(C) only iv
(D) ii and iii
Answer:
(B)

Question 56.
A lab technician was evaluating blood reports of some patients. She observed the following values of the report:

Read the given comments and discuss what disorder/disease the patient must be suffering from.

Answer:

Multiple Choice Questions

Question 1.
Uric acid is the main nitrogenous waste in
(A) birds
(B) cartilaginous fish
(C) mammals
(D) larval amphibians
Answer:
(A) birds

Question 2.
Protonephridia is the excretory organ of
(A) platyhelminthes
(B) coelenterates
(C) arthropods
(D) aschelminthes
Answer:
(A) platyhelminthes

Question 3.
The glomerulus receives blood through the
(A) vasa recta
(B) renal artery
(C) afferent arteriole
(D) efferent arteriole
Answer:
(C) afferent arteriole

Question 4.
More ADH results in
(A) reduced permeability of DCT
(B) dilute urine
(C) reduced blood pressure
(D) concentrated urine
Answer:
(D) concentrated urine

Competitive Corner

Question 1.
Match the items in Column-I with those in Column-II [NEET Odisha 2019]

Select the correct option from the following:
(A) i-d, ii-b, iii-c, iv-a
(B) i-c, ii-d, iiii-b, iv-a
(C) i-c, ii-b, iii-d, iv-a
(D) i-d, ii-c, iii-b, iv-a
Answer:
(D) i-d, ii-c, iii-b, iv-a

Question 2.
Match the following parts of a nephron with their function: [NEET Odisha 2019]

Select the correct option from the following:
(A) i-d, ii-a, iii-c, iv-b
(B) i-a, ii-c, iii-b, iv-d
(C) i-b, ii-d, iii-a, iv-c
(D) i-a, ii-d, iii-b, iv-c
Answer:
(C) i-b, ii-d, iii-a, iv-c

Question 3.
Which of the following factors is responsible for the formation of concentrated urine? [NEET(UG) 2019]
(A) Secretion of erythropoietin by Juxtaglomerular complex.
(B) Hydrostatic pressure during glomerular filtration.
(C) Low levels of antidiuretic hormone.
(D) Maintaining hyperosmolarity towards inner medullary interstitium in the kidneys.
Answer:
(D) Maintaining hyperosmolarity towards inner medullary interstitium in the kidneys.

Question 4.
Portions of renal cortex, which are projected into renal medulla, among the renal pyramids are called as _______. [MHT CET 2019]
(A) Columns of Bertini
(B) Columnae Camae
(C) Ampullae
(D) Ducts of Bellini
Answer:
(A) Columns of Bertini

Question 5.
Renal failure is typically detected by biochemical analysis of blood which shows _______. [MHT CET 2019]
(A) increased level of amino acids
(B) lower level of uric acid
(C) lower level of serum creatinine
(D) higher level of serum creatinine
Answer:
(D) higher level of serum creatinine

Question 6.
Which of the following statements is CORRECT with reference to nephron? [MHT CET 2019]
(A) ADH hormone increases permeability of PCT cells to reabsorb water.
(B) Efferent arteriole forms peritubular network all around tubule.
(C) Podocytes occur in ascending limb of loop of Henle.
(D) Descending limb of Henle’s loop is impenneable to water.
Answer:
(B) Efferent arteriole forms peritubular network all around tubule.

Question 7.
Match the items given in Column I with those in Column li and select the correct option given below. [NFET (UG) 2018]

(A) i-e, ii-d, iii-a, iv-b
(B) i-d, ii-a, iii-b, iv-c
(C) i-d, ii-e, iii-b, iv-c
(D) i-e, ii-d, iii-a, iv-c
Answer:
(B) i-d, ii-a, iii-b, iv-c

Question 8.
Match the items given in Column I with those in Column II and select the correct option given below. [NEET (UG) 2018]

(A) i-b, ii-c, iii-a, iv-d
(B) i-a, ii-b, iii-c, iv-d
(C) i-c, ii-b, iii-d, iv-a
(D) i-d, ii-a, iii-b, iv-c
Answer:
(D) i-d, ii-a, iii-b, iv-c

Question 9.
In the given diagram of Malpighian body, blood is filtered from part labelled ________

(A) L
(B) M
(C) N
(D) O
Hint: L – Afferent arteriole
M – Efferent arteriole
N – Glomerulus
O – Proximal convoluted tubule
Blood filtration occurs in glomerulus. Afferent arteriole is the blood vessel leading to glomerulus. Efferent arteriole carries blood away from the glomerulus. Proximal convoluted tubule is involved in reabsorption of useful substances from the filtrate.
Answer:
(C) N

Question 10.
Majority of kidney stones consist crystals of [MHT CET 2018]
(A) calcium oxalate, sodium bicarbonate
(B) calcium oxalate, calcium phosphate
(C) calcium phosphate, sodium chloride
(D) calcium carbonate, copper sulphate
Answer:
(B) calcium oxalate, calcium phosphate

Question 11.
Which of the following group of animals is guanotelic? [MHT CEE 2018]
(A) Labeo, turtle, camel
(B) Lizard, snake, scorpion
(C) Penguin, spider, scorpion
(D) Spider, scorpion, snake
Answer:
(C) Penguin, spider, scorpion

Question 12.
Which of the following statements is CORRECT? [NEET (UG) 2017]
(A) The ascending limb of loop of Henle is impermeable to water.
(B) The descending limb of loop of Henle is impermeable to water.
(C) The ascending limb of loop of Henle is permeable to water.
(D) The descending limb of loop of Henle is permeable to electrolytes.
Hint: Descending limb of loop of Henle is permeable to water but impermeable to electrolytes. While ascending limb of loop of Henle is impermeable to water and permeable to electrolytes.
Answer:
(A) The ascending limb of loop of Henle is impermeable to water.

Question 13.
A decrease in blood pressure/volume will not cause the release of [NEET (UG) 2017]
(A) Renin
(B) Atrial Natriuretic Factor
(C) Aldosterone
(D) ADH
Hint: Decrease in blood pressure or volume stimulates the release of renin, aldosterone and ADH. ANF is released when blood pressure increases or blood volume increases. Release of ANF causes vasodilation and also inhibit renin angiotensin mechanism that decreases blood pressure and blood volume.
Answer:
(B) Atrial Natriuretic Factor

Question 14.
Formation of urea takes place in the _________. [MHT CET 2017]
(A) Heart
(B) Kidney
(C) Liver
(D) Lung
Answer:
(C) Liver

Question 15.
The yellow colour of normal urine is due to [MHT CET 2017]
(A) Bilirubin
(B) Biliverdin
(C) Urochrome
(D) Uric acid
Answer:

Question 16.
Uremia is indicated when the blood urea level rises above _______ [MHT CET 2017]
(A) 0.05%
(B) 0.04%
(C) 0.03%
(D) 0.02 %
Answer:
(A) 0.05%